Will we ever have painkillers as good as opioids, but without the risk of addiction and overdose?

#opioids #heroin #opioidcrisis

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What Happens When You Overdose?:
https://youtu.be/xLSz3wEgwJ8

Why Are Synthetic Drugs So Dangerous?:
https://www.youtube.com/watch?v=83gIiBD365E

The Top 5 Strangest Poisons That Can Kill You:
https://youtu.be/4hQ0G0GaYR8

Can You Take Expired Drugs?:
https://youtu.be/aT4qzgEQr-Y

What is Addiction?:
https://youtu.be/C6I3CHhBGeQ

Credits:
Executive Producers:
George Zaidan
Hilary Hudson

Producers:
Andrew Sobey
Elaine Seward

Writer/Host:
Sam Jones, PhD

Scientific consultants:
Michelle Boucher, PhD
Kelly Dunn, PhD
Leila Duman, PhD
Kim Janda, PhD

Sources:
Frederich Serturner
https://pubmed.ncbi.nlm.nih.gov/1786314/

Opioid toxicity
https://www.ncbi.nlm.nih.gov/books/NBK431077/

Opioid overdoses–world stats https://www.who.int/news-room/fact-sheets/detail/opioid-overdose#:~:text=difficultieswithbreathing.-,Worldwideabout0.5milliondeathsareattributabletodruguse,ofopioidoverdosein2017

Opioid death rates in the US
https://www.drugabuse.gov/drug-topics/trends-statistics/overdose-death-rates#:~:text=Opioidinvolvedoverdosedeathsrose,in2018with46802deaths.

Inside the Story of America’s 19th-Century Opiate Addiction
https://www.smithsonianmag.com/history/inside-story-americas-19th-century-opiate-addiction-180967673/

Abuse-deterrent opioids
https://pubs.acs.org/doi/10.1021/cen-09545-cover2

NIH solicits research into vaccines that protect against opioid use https://www.genengnews.com/insights/nih-solicits-research-into-vaccines-to-protect-against-opioid-use/

Vaccines against addictive drugs push forward despite past failures
https://cen.acs.org/articles/96/i8/Vaccines-against-addictive-drugs-push.html?utm_source=ACSMembership&utm_medium=Webinar&utm_campaign=CEN

Looking beyond opioids for safer pain relief
https://cen.acs.org/articles/95/i45/chemists-responding-opioid-epidemic.html?utm_source=ACSMembership&utm_medium=Webinar&utm_campaign=CEN

Opioid abuse timeline (FDA)
https://www.fda.gov/drugs/information-drug-class/timeline-selected-fda-activities-and-significant-events-addressing-opioid-misuse-and-abuse

Overdose death rates
https://www.drugabuse.gov/drug-topics/trends-statistics/overdose-death-rates#:~:text=Opioidinvolvedoverdosedeathsrose,in2018with46802deaths.

Prostaglandins
https://chem.libretexts.org/Bookshelves/Biological_Chemistry/Supplemental_Modules_(Biological_Chemistry)/Lipids/Fatty_Acids/Prostaglandins#:~:text=ProstaglandinStructure-,Prostaglandinsareunsaturatedcarboxylicacidsconsistingofofa20,twoorthreedoublebonds.&text=Atypicalstructureisontheleftgraphic.

God’s Own Medicine
https://skepticalinquirer.org/2017/03/gods-own-medicine/

Heroin
https://pubchem.ncbi.nlm.nih.gov/compound/Heroin

Ibuprofen
https://pubchem.ncbi.nlm.nih.gov/compound/Ibuprofen

Oxycodone
https://pubchem.ncbi.nlm.nih.gov/compound/Oxycodone

Heroin chapter
https://www.sciencedirect.com/science/article/pii/B0123693977004568

Structure of ibuprofen bound to COX-2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276492/

Use of Oxycodone in Pain Management
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018705/#:~:text=Oxycodoneisananalgesicopioid,marketin1996(2).

Overcoming opioids: The quest for less addictive drugs
https://www.statnews.com/2017/04/17/opioids-quest-less-addictive-drugs/

Rats prefer sugar to heroin
https://pubmed.ncbi.nlm.nih.gov/28645064/

NIDA heroin info
https://www.drugabuse.gov/sites/default/files/heroinrrs_11_14.pdf

Heroin History
https://www.hazelden.org/HAZ_MEDIA/7988_heroin.pdf

Frontline PBS: Opium throughout history https://www.pbs.org/wgbh/pages/frontline/shows/heroin/etc/history.html

The Ongoing Opioid Prescription Epidemic: Historical Context
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940677/

Heroin’s Addiction’s Fraught History
https://www.theatlantic.com/health/archive/2014/02/heroin-addictions-fraught-history/284001/

Heroin Prescription and History
https://core.ac.uk/reader/189542775?utm_source=linkout

Addiction medications
https://americanaddictioncenters.org/addiction-medications

Opiate history
https://www.michaelshouse.com/opiate-rehab/history-of-opiates/

Death Tolls
https://www.cdc.gov/drugoverdose/epidemic/index.html

Overdose Increases
https://www.cdc.gov/media/releases/2020/p1218-overdose-deaths-covid-19.html

Etanercept
https://www.ncbi.nlm.nih.gov/books/NBK545252/

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